This series started as Legion of Super-Heroes (2005-2006) and then changed its title to Supergirl and the Legion of Super-Heroes in issue #16. Supergirl appeared from issues #16-36, which were collected in four volumes (below). The series continued under the original title after Supergirl’s departure, finishing its run with issue #50. These later issues were not well received due to the change in creative team.
In-universe, Supergirl travelled to the 31st century between Supergirl #5 and #6 of her 2005 series, however this was never referenced in her own series until she regained her memories in Supergirl #21-22 when she encountered an alternate version of the Legionnaires in her own time.
Legion of Super-Heroes Vol. 1: Teenage Revolution
Collects issues #1-6 and and the preview story from Teen Titans/Legion Special #1. Supergirl does not appear.
Legion of Super-Heroes Vol. 2: Death of a Dream
Collects issues #7-13. Supergirl does not appear.
Supergirl & the Legion of Super-Heroes: Strange Visitor From Another Century
The 21st Century’s Girl of Steel wakes up 1,001 years later, convinced the whole reality is something she just dreamed up.
Collects Legion of Super-Heroes #14 and Supergirl and the Legion of Super-Heroes #16-19, plus the “letter column” back-ups from Legion of Super-Heroes #6, 9, 13-15. Not included is issue #15, a flashback issue which highlights three significant stories from various points in Legion history.
Written by Mark Waid and Tony Bedard; Art by Barry Kitson, Adam DeKraker and Mick Gray.
Supergirl & the Legion of Super-Heroes: Adult Education
Collects issues #20-25
In this volume, Brainiac wants to bring the deceased Dream Girl back from the dead, and only the mind of a deadly enemy can help.
Written by Mark Waid and Tony Bedard; Art by Barry Kitson, Mick Gray and various.
Supergirl & the Legion of Super-Heroes: The Dominator War
The Dominators’ plan to destroy Earth reaches fruition as the Robot Rebellion sweeps the planet!
Written by Mark Waid; Art by Barry Kitson and Kalman Andrasofszky; Cover by Kitson.
Supergirl & the Legion of Super-Heroes: The Quest for Cosmic Boy
The Legionnaires’ leader, Cosmic Boy, has disappeared. Was he captured by enemies or has he fled responsibility?
Written by Tony Bedard ; Art by Kevin Sharpe and Dennis Calero ; Cover by Barry Kitson.